Air Pollution May be Raising Risk of Lung Cancer in ‘Never-Smokers’

A new study published in Nature reveals that air pollution, traditional herbal remedies, and environmental contaminants may be contributing to lung cancer in people who have never smoked. Researchers analyzed lung tumors from 871 never-smokers across 28 regions and discovered specific DNA mutation patterns tied to high pollution exposure—many similar to those caused by tobacco use.

Participants living in more polluted areas showed higher rates of cancer-driving mutations and shorter telomeres, a marker of accelerated aging. The study also identified a mutational signature linked to aristolochic acid, a carcinogen found in some traditional medicines, underscoring emerging public health risks and prevention opportunities.